RG7834 (RO 7020322) (Synonyms: RO 7020322) |
| رقم الكتالوجGC32193 |
RG7834 (RO 7020322) (RO 7020322) هو مثبط HBV انتقائي للغاية ومتوفر بيولوجيًا عن طريق الفم ، ويثبط بشكل فعال مستضدات HBV (كل من HBsAg و HBeAg) و HBV DNA ، مع IC50s من 2.8 و 2.6 و 3.2 نانومتر ، على التوالي ، في خلايا dHepaRG.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2072057-17-9
Sample solution is provided at 25 µL, 10mM.
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RG7834 (RO 7020322) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells[1].
RG7834 ((S)-(+)-64) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells[1].RG7834 has no activity against CYP3A4, CYP2D6, CYP2C9 (IC50s >50 μM) or hERG channel[1].
RG7834 (4 mg/kg, twice daily for 21 days) shows anti-HBV efficacy in HBV-infected human liver chimeric uPA-SCID mice[1].RG7834 (2, 14.5 mg/kg, p.o.) exhibits good oral bioavail ability, with a half-life of 4.9 h in mice[1].
[1]. Han X, et al. Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action. J Med Chem. 2018 Oct 4.
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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