RMC-0331 (Synonyms: RM-023) |
| رقم الكتالوجGC62494 |
RMC-0331 (RM-023) هو مثبط SOS1 قوي وانتقائي ومتوفر بيولوجيًا عن طريق الفمRMC-0331 عبارة عن مركب أداة في الجسم الحي يمنع تنشيط RAS عن طريق تعطيل تفاعل RAS-SOS1
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Cas No.: 2488788-52-7
Sample solution is provided at 25 µL, 10mM.
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RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction[1].
RMC-0331 has an IC50 of 71 nM measuring by the rate of GDP/GTP exchange in vitro[1].
RMC-0331 (100-250 mg/kg; p.o.; qd; immunocompetent mice) shows single agent anti-tumor activity in SHP2-mutant models[1].
[1]. Andreas Buckl, et al. Discovery of a Potent, Selective and Orally Bioavailable SOS1 Inhibitor, RMC-0331 (RM-023), an in vivo Tool Compound that Blocks RAS Activation via Disruption of the RAS-SOS1 Interaction.
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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