RMC-4550 |
| رقم الكتالوجGC33044 |
RMC-4550 هو مثبط قوي وانتقائي وخيفي لـ SHP2 ، مع IC50 يبلغ 0.583 نانومتر
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2172651-73-7
Sample solution is provided at 25 µL, 10mM.
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RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.
RMC-4550 is an allosteric inhibitor of SHP2 and stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. Consistent with an allosteric mode of inhibition, RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2[1].
[1]. Nichols RJ, et al. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. Nat Cell Biol. 2018 Sep;20(9):1064-1073.
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