الصفحة الرئيسية>>Signaling Pathways>> Ubiquitination/ Proteasome>> Autophagy>>Rosiglitazone

Rosiglitazone بيع (Synonyms: BRL 49653)

رقم الكتالوجGC16444

منشط PPARγ

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Rosiglitazone التركيب الكيميائي

Cas No.: 122320-73-4

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
36٫00
متوفر
25mg
37٫00
متوفر
100mg
48٫00
متوفر
200mg
79٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description Protocol Chemical Properties Product Documents Related Video Related Products

Rosiglitazone is a potent agonist of peroxisome proliferator-activated receptor γ (PPARγ), a subfamily of the nuclear-receptor superfamily which is predominately expressed in adipose tissue and regulates gene expression responding to ligand binding. Belonging to the thiazolidinedione (TZD) class, rosiglitazone, like other TZD members, binds to PPARγ DNA as heterodimers and activate transcription of various metabolic regulators involved in the differentiation of stem cells into adipocytes and increased expression of genes regulating the metabolism of glucose and lipid. Rosiglitazone is used to treat patients with type II diabetes mellitus for its strong ability to improve insulin sensitization through its effects either on fatty acid uptake and storage in adipose tissue or on adiokines.

Reference

[1].Peter J. Cox, David A. Ryan, Frank J. Hollis, Ann-Marie Harris, Ann K. Miller, Marika Vousden and Hugh Cowley. Absorption, disposition, and metabolism of rosiglitazone, a potent thiazolidinedione insulin sensitizer, in humans. Drug Metabolism and Disposition 2000; 28(7): 772-780
[2].Adie Vilioen and Alan Sinclair. Safety and efficacy of rosiglitazone in the elderly diabetic patient. Vascular Health and Risk Management 2009:5 389-395

مراجعات

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