(S,R,S)-AHPC-Me dihydrochloride (Synonyms: VHL ligand 2 dihydrochloride; E3 ligase Ligand 1 dihydrochloride) |
| رقم الكتالوجGC60426 |
(S ، R ، S) -AHPC-Me ثنائي هيدروكلوريد (VHL ligand 2 dihydrochloride) هو (S ، R ، S) - Ligand القائم على AHPC المستخدم في توظيف بروتين von Hippel-Lindau (VHL)(S ، R ، S) -AHPC-Me ثنائي هيدروكلوريد يمكن استخدامه لتخليق ARV-771 ، وهو مطهر BET PROTAC يعتمد على von Hippel-Landau (VHL) E3يحلل ARV-771 بروتين BET بشكل فعال في خلايا سرطان البروستاتا المقاومة للإخصاء (CRPC) مع DC50 <1 نانومتر
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Sample solution is provided at 25 µL, 10mM.
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(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2].
[1]. Raina K, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7124-9.
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