KT185 |
| رقم الكتالوجGC36401 |
KT185 هو مثبط ABHD6 المتوفر حيوياً عن طريق الفم ، مخترق الدماغ وانتقائي ، مع IC50 0.21 نانومتر في خلايا Neuro2A
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Cas No.: 1472640-86-0
Sample solution is provided at 25 µL, 10mM.
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KT185 is an orally-bioavailable, brain-penetrant and selective ABHD6 inhibitor, with an IC50 0.21 nM in Neuro2A cells[1]. IC50: ABHD6 (0.21 nM in Neuro2A cells)[1].
[1]. Hsu KL, et al. Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6). J Med Chem. 2013 Nov 14;56(21):8270-9.
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