الصفحة الرئيسية>>Lipids>> Sphingolipids>>S1PL-IN-31

S1PL-IN-31 (Synonyms: Sphingosine-1-Phosphate Lyase Inhibitor 31; S1PL Inhibitor 31; S1P Lyase Inhibitor 31)

رقم الكتالوجGC91424 Copy One-Click Copy Product Info

S1PL-IN-31 هو مثبط للسفينجوزين - 1 - فوسفات (S1P) لايز (IC50 = 210 نانومتر).

Products are for research use only. Not for human use. We do not sell to patients.

S1PL-IN-31 التركيب الكيميائي

Cas No.: 1538574-95-6

الحجم السعر المخزون الكميّة
1mg
96٫00
متوفر
5mg
363٫00
متوفر
10mg
629٫00
متوفر

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مراجعات العميل

بناء على آراء العملاء.

Sample solution is provided at 25 µL, 10mM.



Description of S1PL-IN-31

S1PL-IN-31 is an inhibitor of sphingosine-1-phosphate (S1P) lyase (IC50 = 210 nM).1 It is also an antagonist of the Smoothened (Smo) receptor (IC50 = 440 nM). In vivo, S1PL-IN-31 (2 mg/kg per day) prevents cervical and thoracic lymphocyte infiltration and neuromuscular weakness in a rat model of experimental autoimmune encephalomyelitis (EAE) induced by the myelin oligodendrocyte glycoprotein (MOG) peptide MOG29-152. It reduces the total number of lymphocytes, as well as the levels of CD4+ T cells, CD8+ T cells, and B cells in rats. S1PL-IN-31 (100 mg/kg) increases S1P levels in the heart and lymph nodes of male and female rats and decreases heart rate in female rats when administered at doses of 3 and 10 mg/kg per day.2

Chemical Properties of S1PL-IN-31

Cas No. 1538574-95-6 SDF
المرادفات Sphingosine-1-Phosphate Lyase Inhibitor 31; S1PL Inhibitor 31; S1P Lyase Inhibitor 31
Formula C26H23ClN6 M.Wt 455
الذوبان Acetonitrile: Soluble,DMSO: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of S1PL-IN-31

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.1978 mL 10.989 mL 21.978 mL
5 mM 439.6 μL 2.1978 mL 4.3956 mL
10 mM 219.8 μL 1.0989 mL 2.1978 mL
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In vivo Formulation Calculator (Clear solution) of S1PL-IN-31

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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