Sappanchalcone |
| رقم الكتالوجGC64645 |
سابانشالكون ، فلافونويد معزول من Caesalpinia sappan L. ، يحفز موت الخلايا المبرمج المعتمد على الكاسبيز والمعتمد على AIF في خلايا سرطان القولون البشرية.
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Cas No.: 94344-54-4
Sample solution is provided at 25 µL, 10mM.
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Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells[1].
Sappanchalcone has a statistically significant effect on HCT116 cells than on SW480 cells (IC50= 37.33 μM and 54.23 μM, respectively). Sappanchalcone reduces MMP with a significant increase in ROS levels in human colon cancer cells. Sappanchalcone triggered phosphorylation of p53, which is involved in the activation of caspases and increased expression of Bax in HCT116 cells[1].
[1]. Seo HW, et al. Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells. Chem Biol Interact. 2020;327:109185.
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