SBI-0640756 (Synonyms: SBI-756) |
رقم الكتالوجGC19451 |
SBI-0640756 (SBI-756) هو مثبط لـ eIF4G1 ويعطل مجمع eIF4F
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Cas No.: 1821280-29-8
Sample solution is provided at 25 µL, 10mM.
SBI-0640756 is a water soluble inhibitor of eIF4G1 and disrupts the eIF4F complex.
SBI-0640756 is a water soluble inhibitor of eIF4G1. SBI-0640756 (0-1 μM) disrupts eIF4F complex in parent and BRAFi-resistant melanoma. SBI-0640756 shows inhibitory effect on human melanoma lines, and also suppresses AKT, NF-κB and AKT/mTORC1 activity[1].
SBI-0640756 (0.5 mg/kg, i.p.) delays tumor onset and reduces tumor incidence by 50% in NrasQ61K/Ink4a-/- genetic model. SBI-0640756 (1 mg/kg, 2 times per week, i.p.) in combination with BRAF inhibitor potently suppresses growth of established tumors and does not resume tumor growth in immunodeficient mice bearing A375 tumors[1].
[1]. Feng Y et al. SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Res, 2015 Dec 15, 75(24):5211-8.
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