SBI-477 |
| رقم الكتالوجGC39147 |
SBI-477 عبارة عن مسبار كيميائي يحفز إشارات الأنسولين عن طريق إلغاء تنشيط عامل النسخ MondoA ، مما يؤدي إلى تقليل التعبير عن مثبطات مسار الأنسولين (TXNIP) ومجال الإيقاف - الذي يحتوي على 4 (ARRDC4)
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Cas No.: 781628-99-7
Sample solution is provided at 25 µL, 10mM.
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SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes[1].
[1]. Ahn B, et al. MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling. J Clin Invest. 2016 Sep 1;126(9):3567-79.
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