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SGA360

رقم الكتالوجGC18821 Copy One-Click Copy Product Info

يقوم SGA360 بقمع إشارات SAA1 الالتهابية بطريقة تعتمد على AHR من خلال آلية لا تتطلب ارتباط AHR بعنصر الاستجابة المتعارف عليه (المضاد الجزئي)

Products are for research use only. Not for human use. We do not sell to patients.

SGA360 التركيب الكيميائي

Cas No.: 680611-86-3

الحجم السعر المخزون الكميّة
1mg
85٫00
متوفر
5mg
271٫00
متوفر
10mg
447٫00
متوفر
25mg
926٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


مراجعات العميل

بناء على آراء العملاء.

Sample solution is provided at 25 µL, 10mM.



Description of SGA360

SGA360 is a selective modulator of the aryl hydrocarbon receptor (AhR), which is a ligand-dependent transcription factor that mediates the toxicity of certain xenobiotics and polyaromatic hydrocarbons. SGA360 competitively binds to AhR (IC50 = 3 uM) and represses serum amyloid A 1 (SAA1) gene expression induced by IL-1β in Huh7 cells. It also reduces inflammation and decreases the mRNA expression of the inflammatory mediators COX-2, IL-6, IL-1β, SAA3, and IL-10 in wild-type, but not AhR knockout, mice in a model of inflammatory ear edema. SGA360 also reduces acute inflammation in murine models of septic shock, gout, and peritonitis when the high-affinity AhR variant is expressed.

Chemical Properties of SGA360

Cas No. 680611-86-3 SDF
Chemical Name 3-(2,4-dimethoxyphenyl)-1-(2-propen-1-yl)-7-(trifluoromethyl)-1H-indazole
Canonical SMILES C=CCN1N=C(C2=CC=C(OC)C=C2OC)C3=CC=CC(C(F)(F)F)=C31
Formula C19H17F3N2O2 M.Wt 362.4
الذوبان DMF: 20 mg/ml,DMF:PBS(pH7.2) (1:2): 0.33 mg/ml,DMSO: 10 mg/ml,Ethanol: 2.5 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of SGA360

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.7594 mL 13.7969 mL 27.5938 mL
5 mM 551.9 μL 2.7594 mL 5.5188 mL
10 mM 275.9 μL 1.3797 mL 2.7594 mL
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** عند إعداد حلول المخزون، دائمًا استخدم الوزن الجزيئي الخاص بالدفعة للمنتج على ملصق القارورة MSDS / CoA (متوفر عبر الإنترنت).

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In vivo Formulation Calculator (Clear solution) of SGA360

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % saline
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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مراجعات

Review for SGA360

Average Rating: 5 ★★★★★ (Based on Reviews and 36 reference(s) in Google Scholar.)

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