SGA360 |
| رقم الكتالوجGC18821 |
يقوم SGA360 بقمع إشارات SAA1 الالتهابية بطريقة تعتمد على AHR من خلال آلية لا تتطلب ارتباط AHR بعنصر الاستجابة المتعارف عليه (المضاد الجزئي)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 680611-86-3
Sample solution is provided at 25 µL, 10mM.
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SGA360 is a selective modulator of the aryl hydrocarbon receptor (AhR), which is a ligand-dependent transcription factor that mediates the toxicity of certain xenobiotics and polyaromatic hydrocarbons. SGA360 competitively binds to AhR (IC50 = 3 uM) and represses serum amyloid A 1 (SAA1) gene expression induced by IL-1β in Huh7 cells. It also reduces inflammation and decreases the mRNA expression of the inflammatory mediators COX-2, IL-6, IL-1β, SAA3, and IL-10 in wild-type, but not AhR knockout, mice in a model of inflammatory ear edema. SGA360 also reduces acute inflammation in murine models of septic shock, gout, and peritonitis when the high-affinity AhR variant is expressed.
Review for SGA360
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
Review for SGA360
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