SGA360 |
| Katalog-Nr.GC18821 |
SGA360 unterdrÜckt die entzÜndliche SAA1-Signalgebung auf AHR-abhÄngige Weise durch einen Mechanismus, der keine AHR-Bindung an sein zugehÖriges Response-Element (partieller Antagonist) erfordert.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 680611-86-3
Sample solution is provided at 25 µL, 10mM.
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SGA360 is a selective modulator of the aryl hydrocarbon receptor (AhR), which is a ligand-dependent transcription factor that mediates the toxicity of certain xenobiotics and polyaromatic hydrocarbons. SGA360 competitively binds to AhR (IC50 = 3 uM) and represses serum amyloid A 1 (SAA1) gene expression induced by IL-1β in Huh7 cells. It also reduces inflammation and decreases the mRNA expression of the inflammatory mediators COX-2, IL-6, IL-1β, SAA3, and IL-10 in wild-type, but not AhR knockout, mice in a model of inflammatory ear edema. SGA360 also reduces acute inflammation in murine models of septic shock, gout, and peritonitis when the high-affinity AhR variant is expressed.
Review for SGA360
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
Review for SGA360
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