SIRT2-IN-9 |
| رقم الكتالوجGC66026 |
SIRT2-IN-9 (المركب 12) هو مثبط انتقائي لـ SRIT2 بقيمة IC50 1.3 μ ؛ M. يمنع SIRT2-IN-9 النشاط التكاثري لخلايا سرطان الثدي MCF-7. يمكن استخدام SIRT2-IN-9 في أبحاث السرطان.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 522650-91-5
Sample solution is provided at 25 µL, 10mM.
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SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer[1].
SIRT2-IN-9 (1-100 μM; 15 min) dose-dependently inhibits SRIT2 with an IC50 value of 1.3 μM, and inhibits SRIT1 and SRIT3 with IC50s ??300 μM[1].
SIRT2-IN-9 (0-50 μM; 72 h) affects cell viability of MCF-7 cells[1].
SIRT2-IN-9 (0-50 μM; 6 h) affects acetylation of α-tubulin protein[1].
Cell Proliferation Assay[1]
| Cell Line: | MCF-7 breast cancer cell line |
| Concentration: | 0-50 μM |
| Incubation Time: | 72 hours |
| Result: | Dose-dependently inhibited cell proliferation of MCF-7 breast cancer cells. |
Western Blot Analysis[1]
| Cell Line: | MCF-7 breast cancer cell line |
| Concentration: | 6.25, 12.5, 25 and 50 μM |
| Incubation Time: | 6 hours |
| Result: | Dose-dependently increased acetylation of α-tubulin protein. |
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