SIRT2-IN-9 |
| カタログ番号GC66026 |
SIRT2-IN-9 (化合物 12) は SRIT2 の選択的阻害剤であり、IC50 値は 1.3 μM. SIRT2-IN-9 は、MCF-7 乳癌細胞の増殖活性を阻害します。 SIRT2-IN-9 はがんの研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 522650-91-5
Sample solution is provided at 25 µL, 10mM.
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SIRT2-IN-9 (compound 12) is a selective inhibitor of SRIT2 with an IC50 value of 1.3 μM. SIRT2-IN-9 inhibits proliferative activity of MCF-7 breast cancer cells. SIRT2-IN-9 can be used for the research of cancer[1].
SIRT2-IN-9 (1-100 μM; 15 min) dose-dependently inhibits SRIT2 with an IC50 value of 1.3 μM, and inhibits SRIT1 and SRIT3 with IC50s ??300 μM[1].
SIRT2-IN-9 (0-50 μM; 72 h) affects cell viability of MCF-7 cells[1].
SIRT2-IN-9 (0-50 μM; 6 h) affects acetylation of α-tubulin protein[1].
Cell Proliferation Assay[1]
| Cell Line: | MCF-7 breast cancer cell line |
| Concentration: | 0-50 μM |
| Incubation Time: | 72 hours |
| Result: | Dose-dependently inhibited cell proliferation of MCF-7 breast cancer cells. |
Western Blot Analysis[1]
| Cell Line: | MCF-7 breast cancer cell line |
| Concentration: | 6.25, 12.5, 25 and 50 μM |
| Incubation Time: | 6 hours |
| Result: | Dose-dependently increased acetylation of α-tubulin protein. |
| Cas No. | 522650-91-5 | SDF | |
| Formula | C21H22N6OS2 | M.Wt | 438.57 |
| 溶解度 | DMSO : 4.46 mg/mL (10.17 mM; ultrasonic and warming and heat to 70°C) | Storage | 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.2801 mL | 11.4007 mL | 22.8014 mL |
| 5 mM | 0.456 mL | 2.2801 mL | 4.5603 mL |
| 10 mM | 0.228 mL | 1.1401 mL | 2.2801 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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