SLV 320 (Synonyms: SLV 320) |
| رقم الكتالوجGC14290 |
SLV 320 (SLV 320) هو أحد مضادات مستقبلات الأدينوزين A1 القوية والانتقائية والنشطة عن طريق الفم ، مع قيم Ki تبلغ 1 نانومتر و 200 نانومتر و 398 نانومتر لمستقبلات A1 و A3 و A2A البشرية على التوالي.
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Cas No.: 251945-92-3
Sample solution is provided at 25 µL, 10mM.
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Derenofylline (SLV 320) is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2A receptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1].
References:
[1]. Kalk P, et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151(7):1025-32.
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