Spermidine-d6 |
رقم الكتالوجGC49341
One-Click Copy Product Info
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An internal standard for the quantification of spermidine
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2514812-10-1
Sample solution is provided at 25 µL, 10mM.
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Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine.1 It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay.1 It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans.2 Spermidine (30 mM in the drinking water) reduces demyelination of the optic nerve and disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).3 It reduces increases in blood pressure, left ventricular posterior wall thickness, and heart weight in salt-sensitive Dahl rats fed a high-salt diet, a model of hypertension-induced congestive heart failure.4 Formulations containing spermidine have been used as dietary supplements.
1.Madeo, F., Eisenberg, T., Pietrocola, F., et al.Spermidine in health and diseaseScience359(6374)eaan2788(2018) 2.Eisenberg, T., Knauer, H., Schauer, A., et al.Induction of autophagy by spermidine promotes longevityNat. Cell Biol.11(11)1305-1314(2009) 3.Guo, X., Harada, C., Namekata, K., et al.Spermidine alleviates severity of murine experimental autoimmune encephalomyelitisInvest. Ophthalmol. Vis. Sci.52(5)2696-2703(2011) 4.Eisenberg, T., Abdellatif, M., Schroeder, S., et al.Cardioprotection and lifespan extension by the natural polyamine spermidineNat. Med.22(12)1428-1438(2016)
| Cas No. | 2514812-10-1 | SDF | |
| Canonical SMILES | NCCCCNC([2H])(C([2H])(C([2H])(N)[2H])[2H])[2H] | ||
| Formula | C7H13D6N3 | M.Wt | 151.3 |
| الذوبان | Water: 50 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 6.6094 mL | 33.0469 mL | 66.0939 mL |
| 5 mM | 1.3219 mL | 6.6094 mL | 13.2188 mL |
| 10 mM | 660.9 μL | 3.3047 mL | 6.6094 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solution in water
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)