Sphingosine (d14:1) (Synonyms: D-erythro-Sphingosine C14) |
| رقم الكتالوجGC44930 |
السفينغوزين (d14: 1) (Tetradecasphing-4-enine) ، سفينغوليبيد ، هو مثبط قوي لبروتين كيناز سي (PKC)يمنع Sphingosine (d14: 1) تفاعله مع sn-1،2-diacylglycerol (DAG) / Phorbol esters
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Cas No.: 24558-60-9
Sample solution is provided at 25 µL, 10mM.
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Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fungus, with an EC50 value of 10.2 nM. Sphingosine (d14:1) inhibits protein kinase C (PKC) in vitro (IC50 = 7.3 mol%) as well as superoxide generation induced by phorbol 12-myristate 13-acetate in neutrophils and reduces growth of CHO cells (IC50s = 19 and 8 μM, respectively).
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