Sphingosine (d14:1) (Synonyms: D-erythro-Sphingosine C14) |
| Catalog No.GC44930 |
La sphingosine (d14:1) (Tetradecasphing-4-enine), un sphingolipide, est un puissant inhibiteur de la protéine kinase C (PKC). La sphingosine (d14:1) empêche son interaction avec les esters de sn-1,2-diacylglycérol (DAG)/Phorbol.
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Cas No.: 24558-60-9
Sample solution is provided at 25 µL, 10mM.
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Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fungus, with an EC50 value of 10.2 nM. Sphingosine (d14:1) inhibits protein kinase C (PKC) in vitro (IC50 = 7.3 mol%) as well as superoxide generation induced by phorbol 12-myristate 13-acetate in neutrophils and reduces growth of CHO cells (IC50s = 19 and 8 μM, respectively).
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