SUVN-911 |
| رقم الكتالوجGC39575 |
SUVN-911 هو مضاد لمستقبلات النيكوتين العصبي أسيتيل كولين α4β2 قوي ، انتقائي ، مخترق بيولوجيًا ومتوفر بيولوجيًا ، مع Ki 1.5 نانومتر
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Cas No.: 2414674-71-6
Sample solution is provided at 25 µL, 10mM.
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SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a Ki of 1.5 nM. SUVN-911 has antidepressant activity[1].
[1]. Ramakrishna Nirogi, et al. Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine α4β2 Receptor Antagonist for the Treatment of Depression. J Med Chem. 2020 Mar 26;63(6):2833-2853.
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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