SW157765 |
| رقم الكتالوجGC66470 |
SW157765 هو مثبط GLUT8 (SLC2A8) لنقل الجلوكوز غير المتعارف عليه. تعد خلايا KRAS / KEAP1 مزدوجة الطور NSCLC حساسة بشكل انتقائي لـ SW157765 ، نظرًا للنتائج المتقاربة لتعديل KRAS و NRF2 المزدوج لبرامج تنظيم الجينات الأيضية والحيوية.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 332063-87-3
Sample solution is provided at 25 µL, 10mM.
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SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs[1][2].
SW157765-sensitive NSCLC cell lines are also selectively sensitive to glucose deprivation and to GLUT8 depletion. SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner[1].
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