SW157765 |
| Catalog No.GC66470 |
SW157765 es un inhibidor selectivo no canÓnico del transportador de glucosa GLUT8 (SLC2A8). Las células de NSCLC doble mutante KRAS/KEAP1 son selectivamente sensibles a SW157765, debido a las consecuencias convergentes de la modulaciÓn dual KRAS y NRF2 de los programas reguladores de genes metabÓlicos y xenobiÓticos.
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Cas No.: 332063-87-3
Sample solution is provided at 25 µL, 10mM.
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SW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs[1][2].
SW157765-sensitive NSCLC cell lines are also selectively sensitive to glucose deprivation and to GLUT8 depletion. SW157765 selectively inhibits fluorescent 2-deoxyglucose (2DG) uptake in SW157765-sensitive cells in a dose-dependent manner[1].
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