TED-347 |
| رقم الكتالوجGC39540 |
TED-347 هو مثبط قوي وغير قابل للانعكاس وتساهمي وخيفي في تفاعل البروتين والبروتين YAP-TEAD مع EC50 من 5.9 ميكرومتر لتفاعل البروتين والبروتين TEAD4⋅Yap1يرتبط TED-347 على وجه التحديد وبشكل تساهمي بـ Cys-367 داخل الجيب المركزي لـ TEAD4 مع Ki يبلغ 10.3 ميكرومتريحظر TED-347 نشاط نسخ TEAD وله نشاط مضاد للأورام
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Cas No.: 2378626-29-8
Sample solution is provided at 25 µL, 10mM.
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TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity[1].
[1]. Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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