TED-347 |
رقم الكتالوجGC39540
One-Click Copy Product Info
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TED-347 هو مثبط قوي وغير قابل للانعكاس وتساهمي وخيفي في تفاعل البروتين والبروتين YAP-TEAD مع EC50 من 5.9 ميكرومتر لتفاعل البروتين والبروتين TEAD4⋅Yap1يرتبط TED-347 على وجه التحديد وبشكل تساهمي بـ Cys-367 داخل الجيب المركزي لـ TEAD4 مع Ki يبلغ 10.3 ميكرومتريحظر TED-347 نشاط نسخ TEAD وله نشاط مضاد للأورام
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2378626-29-8
Sample solution is provided at 25 µL, 10mM.
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TED-347 is a potent, irreversible, covalent and allosteric inhibitor at YAP-TEAD protein-protein interaction with an EC50 of 5.9 μM for TEAD4⋅Yap1 protein-protein interaction. TED-347 specifically and covalently bonds with Cys-367 within the central pocket of TEAD4 with a Ki of 10.3 μM. TED-347 blocks TEAD transcriptional activity and has antitumor activity[1].
[1]. Khuchtumur Bum-Erdene, et al. Small-Molecule Covalent Modification of Conserved Cysteine Leads to Allosteric Inhibition of the TEAD⋅Yap Protein-Protein Interaction. Cell Chem Biol. 2019 Mar 21;26(3):378-389.e13.
| Cas No. | 2378626-29-8 | SDF | |
| Canonical SMILES | O=C(C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2)CCl | ||
| Formula | C15H11ClF3NO | M.Wt | 313.7 |
| الذوبان | DMSO: 250 mg/mL (796.94 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.1878 mL | 15.9388 mL | 31.8776 mL |
| 5 mM | 637.6 μL | 3.1878 mL | 6.3755 mL |
| 10 mM | 318.8 μL | 1.5939 mL | 3.1878 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)