Tesaglitazar (Synonyms: AZ 242) |
| رقم الكتالوجGC18037 |
Tesaglitazar عبارة عن ناهض ألفا / جاما تنشيط بيروكسيسوم مزدوج (PPAR) وهو أكثر فعالية على PPARγ مقارنة بـ PPARα ، مع EC50s من 13.4 ميكرومتر و 3.6 ميكرومتر للفئران PPARα و PPARα البشري ، على التوالي ، وحوالي 0.2 ميكرومتر لكلا الجرذان و PPARγ البشري
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Cas No.: 251565-85-2
Sample solution is provided at 25 µL, 10mM.
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Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1].
References:
[1]. Hellmold H, et al. Tesaglitazar, a PPARalpha/gamma agonist, induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats. Toxicol Sci. 2007 Jul;98(1):63-74.
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