Tesaglitazar (Synonyms: AZ 242) |
| Catalog No.GC18037 |
Tesaglitazar는 PPARα보다 PPARγ에 더 강력한 이중 퍼옥시좀 증식자 활성화 수용체(PPAR) 알파/감마 작용제이며, EC50은 쥐 PPARα와 인간 PPARα에 대해 각각 13.4μM 및 3.6μM, 두 쥐 모두에 대해 약 0.2μM입니다. 및 인간 PPARγ.
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Cas No.: 251565-85-2
Sample solution is provided at 25 µL, 10mM.
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Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1].
References:
[1]. Hellmold H, et al. Tesaglitazar, a PPARalpha/gamma agonist, induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats. Toxicol Sci. 2007 Jul;98(1):63-74.
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