Thiol-PEG-CH2COOH (MW 5000) |
| رقم الكتالوجGC61333 |
Thiol-PEG-CH2COOH (MW 5000) هو رابط PROTAC قائم على PEG ويمكن استخدامه في تركيب PROTACs
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Sample solution is provided at 25 µL, 10mM.
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Thiol-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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