TMCB |
| رقم الكتالوجGC16413 |
TMCB هو مثبط CK2 انتقائي (كازين كيناز II) منافس لـ ATP مع قيم Ki مميزة تبلغ 83 نانومتر و 21 نانومتر للوحدتين الفرعيتين CK2 المختلفتين α و α '، على التوالي
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 905105-89-7
Sample solution is provided at 25 µL, 10mM.
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TMCB is a dual inhibitor of casein kinase 2 (CK2) and ERK8 (IC50 = 0.5 µM for both).[1] It also binds to Pim-1, HIPK2, and DYRK1A (Kis = 8.65, 15.25, and 11.9 µM, respectively) and inhibits greater than 50% of the activity of five kinases, including CK2, ERK8, and DYRK2, in a panel of 78 kinases at 10 µM. TMCB induces apoptosis in Jurkat cells when used at concentrations ranging from 10 to 50 µM.
Reference:
[1]. Pagano, M.A., Bain, J., Kazimierczuk, Z., et al. The selectivity of inhibitors of protein kinase CK2: An update. Biochem. J. 415(3), 353-365 (2008).
| Cas No. | 905105-89-7 | SDF | |
| Chemical Name | 4,5,6,7-tetrabromo-2-(dimethylamino)-1H-benzimidazole-1-acetic acid | ||
| Canonical SMILES | CN(C1=NC2=C(Br)C(Br)=C(Br)C(Br)=C2N1CC(O)=O)C | ||
| Formula | C11H9Br4N3O2 | M.Wt | 534.82 |
| الذوبان | 25mM in DMSO | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.8698 mL | 9.3489 mL | 18.6979 mL |
| 5 mM | 374 μL | 1.8698 mL | 3.7396 mL |
| 10 mM | 187 μL | 934.9 μL | 1.8698 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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