Tranexamic Acid (Synonyms: AMCA, TXA) |
| رقم الكتالوجGC12905 |
حمض الترانيكساميك (ترانسامين) هو مضاد لحل الفبرين لمنع مواقع ربط اللايسين من البلازمين وشظايا البلازمينوجين المشتقة من الإيلاستاز مع IC 50 من 5 ملي مولار
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Cas No.: 1197-18-8
Sample solution is provided at 25 µL, 10mM.
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Tranexamic acid (Transamin) is an antifibrinolytic for blocking lysine-binding sites of plasmin and elastase-derived plasminogen fragments with IC50 of 5 mM. Target: OthersTranexamic acid is a synthetic derivative of the amino acid lysine. Tranexamic acid is frequently used in surgeries with high risk of blood loss such as cardiac, liver, vascular and large orthopedic procedures. Its oral form is now being evaluated for use in outpatient conditions involving heavy bleeding.Toxicity/Adverse event: Rare in general, including gastrointestinal effects, dizziness, fatigue, headache, and hypersensitivity reactions. Use of tranexamic acid has a potential risk of thrombosis.
References:
[1]. Bhat A, et al. Tranexamic acid overdosage-induced generalized seizure in renal failure. Saudi J Kidney Dis Transpl. 2014 Jan-Feb;25(1):130-2.
[2]. Couturier R, et al. Continuous or discontinuous tranexamic acid effectively inhibits fibrinolysis in children undergoing cardiac surgery with cardiopulmonary bypass. Blood Coagul Fibrinolysis. 2014 Jan 13.
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