Trastuzumab emtansine |
| رقم الكتالوجGC61490 |
Trastuzumab emtansine (Ado-Trastuzumab emtansine) هو مركب مضاد للأدوية (ADC) يتضمن خصائص مضادات الأورام المستهدفة HER2 من تراستوزوماب مع النشاط السام للخلايا للعامل المثبط للأنابيب الدقيقة DM1 (أحد مشتقات المايتانسين)يمكن استخدام Trastuzumab emtansine في البحث عن سرطان الثدي المتقدم
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1018448-65-1
Sample solution is provided at 25 µL, 10mM.
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Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer[1][2].
Trastuzumab emtansine (2 μg/mL; 3 d) significantly inhibits the proliferation of epithelial ovarian cancer (EOC) cells[2].
Trastuzumab emtansine (15 mg/kg; i.v. three to five times weekly for 3 weeks) exhibits significantly anti-tumor effect in mice[2]. Animal Model: CB-17/SCID mice (6 weeks) were injected with OVA10 cells[2]
[1]. Verma S, et, al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med. 2012 Nov 8;367(19):1783-91. [2]. Menderes G, et, al. Superior in vitro and in vivo activity of trastuzumab-emtansine (T-DM1) in comparison to trastuzumab, pertuzumab and their combination in epithelial ovarian carcinoma with high HER2/neu expression. Gynecol Oncol. 2017 Oct;147(1):145-152.
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