Trastuzumab emtansine |
| Catalog No.GC61490 |
Trastuzumab emtansine (Ado-Trastuzumab emtansine) es un conjugado de anticuerpo y fÁrmaco (ADC) que incorpora las propiedades antitumorales de trastuzumab dirigidas a HER2 con la actividad citotÓxica del agente inhibidor de microtÚbulos DM1 (derivado de maitansina). Trastuzumab emtansine se puede utilizar para la investigaciÓn del cÁncer de mama avanzado.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1018448-65-1
Sample solution is provided at 25 µL, 10mM.
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Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that incorporates the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of the microtubule-inhibitory agent DM1 (derivative of maytansine). Trastuzumab emtansine can be used for the research of advanced breast cancer[1][2].
Trastuzumab emtansine (2 μg/mL; 3 d) significantly inhibits the proliferation of epithelial ovarian cancer (EOC) cells[2].
Trastuzumab emtansine (15 mg/kg; i.v. three to five times weekly for 3 weeks) exhibits significantly anti-tumor effect in mice[2]. Animal Model: CB-17/SCID mice (6 weeks) were injected with OVA10 cells[2]
[1]. Verma S, et, al. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med. 2012 Nov 8;367(19):1783-91. [2]. Menderes G, et, al. Superior in vitro and in vivo activity of trastuzumab-emtansine (T-DM1) in comparison to trastuzumab, pertuzumab and their combination in epithelial ovarian carcinoma with high HER2/neu expression. Gynecol Oncol. 2017 Oct;147(1):145-152.
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
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