VU0409551 (Synonyms: JNJ-46778212) |
| رقم الكتالوجGC18412 |
VU0409551 (VU 0409551) هو مُعدِّل خيفي موجب mGlu5 مع EC50 يبلغ 260 نانومتر.
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Cas No.: 1363281-27-9
Sample solution is provided at 25 µL, 10mM.
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JNJ-46778212 (VU 0409551) is an mGlu5 positive allosteric modulator with an EC50 of 260 nM.
In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration[1]. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR−/− mice. The administration of JNJ-46778212 to SR−/− mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory[2].
References:
[1]. Conde-Ceide S, et al. Discovery of VU0409551/JNJ-46778212: An mGlu5 Positive Allosteric Modulator Clinical Candidate Targeting Schizophrenia. ACS Med Chem Lett. 2015 May 20;6(6):716-20.
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