الصفحة الرئيسية>>Signaling Pathways>> GPCR/G protein>> 5-HT Receptor>>VUF 10166

VUF 10166

رقم الكتالوجGC13501

VUF 10166 هو مضاد لمستقبلات 5-HT3 قوي وعالي التقارب ، مع قيم Ki تبلغ 0.04 نانومتر (5-HT3A) و 22 نانومتر (5-HT3AB).

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VUF 10166 التركيب الكيميائي

Cas No.: 155584-74-0

الحجم السعر المخزون الكميّة
10mg
52٫00
متوفر
50mg
245٫00
متوفر
500mg
824٫00
متوفر
1g
1236٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of VUF 10166

VUF10166 is a novel, potent and competitive antagonist for 5-HT3A receptor with Ki of 0.04 nM, its affinity at 5-HT3AB receptor is significantly lower.

Chemical Properties of VUF 10166

Cas No. 155584-74-0 SDF
Chemical Name 2-chloro-3-(4-methylpiperazin-1-yl)quinoxaline
Canonical SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3N=C2Cl
Formula C13H15ClN4 M.Wt 262.74
الذوبان ≥ 26.3mg/mL in EtOH Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of VUF 10166

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.806 mL 19.0302 mL 38.0604 mL
5 mM 0.7612 mL 3.806 mL 7.6121 mL
10 mM 0.3806 mL 1.903 mL 3.806 mL
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In vivo Formulation Calculator (Clear solution) of VUF 10166

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Review for VUF 10166

Average Rating: 5 ★★★★★ (Based on Reviews and 22 reference(s) in Google Scholar.)

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