WM-3835 |
| رقم الكتالوجGC62104 |
WM-3835 هو مثبط قوي وعالي النوعية لـ HBO1 (KAT7 أو MYST2) ويرتبط مباشرة بموقع ارتباط أسيتيل CoA لـ HBO1 33. ينشط WM-3835 موت الخلايا المبرمج بينما يمنع تكاثر الخلايا الساركوما العظمية (OS) والهجرة والغزوWM-3835 له نشاط مضاد للأورام ويثبط بشكل فعال نمو طعم أجنبي pOS-1 في الفئران
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2229025-70-9
Sample solution is provided at 25 µL, 10mM.
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WM-3835 is a potent and high-specific HBO1 (KAT7 or MYST2) inhibitor and binds directly to the acetyl-CoA binding site of HBO1 33. WM-3835 activates apoptosis while inhibits osteosarcoma (OS) cell proliferation, migration and invasion. WM-3835 has antitumor activity and potently inhibits pOS-1 xenograft growth in mice[1].
WM-3835 (1-25 uM; 24-96 hours) inhibits pOS-1 cell viability in a concentration-dependent manner[1]. WM-3835 (5 uM; 72 h) activates cell apoptosis and significantly increases TUNEL-positive nuclei in pOS-1 cells[1]. WM-3835 (5 µM; 24 hours) downregulates MYLK-HOXA9 mRNA expression in pOS-1 cells[1]. WM-3835 (1-25 uM) suppresses H4K12ac-H3K14ac in a dose-dependent manner. WM-3835 does not alter the expressions of HBO1 protein and total H3, H4 histones[1]. WM-3835 (5 µM) fails to induce apoptosis and reduction of viability in HBO1-KO pOS-1 cells, koHBO1-1 and koHBO1-2, HBO1-low human osteoblasts[1].
WM-3835 (10 mg/kg/day; ip; for21 days) potently inhibits pOS-1 xenograft growth in SCID mice[1].
[1]. Yan-Yang Gao, et al. The histone acetyltransferase HBO1 functions as a novel oncogenic gene in osteosarcoma. Theranostics. 2021 Mar 4;11(10):4599-4615.
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