XEN723 |
| رقم الكتالوجGC31521 |
XEN723 هو مثبط جديد وقوي للثيازوليليميدازوليدينون من Stearoyl-CoA Desaturase (SCD1) مع IC50s من 45 و 524 نانومتر في خلية الفأر و HepG2 ، على التوالي
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Cas No.: 1072803-08-7
Sample solution is provided at 25 µL, 10mM.
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XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.
XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively. XEN723 demonstrates an improvement in SCD1 in vitro potency of more than 560-fold compare to the original high throughput screen (HTS) hit[1].
[1]. Sun S, et al. Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. Bioorg Med Chem Lett. 2014 Jan 15;24(2):520-5.
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