XEN723 |
| カタログ番号GC31521 |
XEN723 は、マウスおよび HepG2 細胞でそれぞれ 45 および 524 nM の IC50 を持つ、ステアロイル CoA デサチュラーゼ (SCD1) の新規かつ強力なチアゾリルイミダゾリジノン阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1072803-08-7
Sample solution is provided at 25 µL, 10mM.
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XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively.
XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively. XEN723 demonstrates an improvement in SCD1 in vitro potency of more than 560-fold compare to the original high throughput screen (HTS) hit[1].
[1]. Sun S, et al. Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases. Bioorg Med Chem Lett. 2014 Jan 15;24(2):520-5.
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