الصفحة الرئيسية>>Signaling Pathways>> Stem Cell>> Wnt/β-catenin>>YB-0158

YB-0158 (Synonyms: Wnt pathway inhibitor 2)

رقم الكتالوجGC63303

YB-0158 (مثبط مسار Wnt 2) عبارة عن محاكٍ للببتيد العكسي وعامل استهداف الخلايا الجذعية لسرطان القولون والمستقيم (CSC)يعطل YB-0158 تفاعلات Sam68-Src ويحفز موت الخلايا المبرمج في خلايا CRCالأنشطة المضادة للسرطان

Products are for research use only. Not for human use. We do not sell to patients.

YB-0158 التركيب الكيميائي

Cas No.: 1144043-83-3

الحجم السعر المخزون الكميّة
5 mg
638٫00
متوفر
10 mg
1020٫00
متوفر
50 mg
3562٫00
متوفر
100mg
5700٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com

مراجعات العميل

بناء على آراء العملاء.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description Protocol Chemical Properties Product Documents

YB-0158 is known as Wnt pathway inhibitor 2. YB-0158 is a peptidomimetic structure with high predicted affinity for Sam68 [1].

YB-0158 elicits a cancer-selective response impeding main cancer stem cell hallmarks [1].

YB-0158 displayed enhanced selective toxicity in colorectal cancer models vs. normal intestinal epithelium progenitor cells. YB-0158 exert negative impact on cancer cell growth by inducing apoptosis and reducing proliferation. YB-0158 eradicated CSCs activity in vivo by a syngeneic mouse-to-mouse serial transplantation assay [2].

References:
[1]. Angelique N. Masibag, Christopher J. Bergin, Joshua R. Haebe, AÏcha Zouggar, Muhammad S. Shah, Tamara Sandouka, Amanda Mendes da Silva, FranÇois M. Desrochers, Aube Fournier-Morin, Yannick D. Benoit.Pharmacological targeting of Sam68 functions in colorectal cancer stem cells. iScience, Volume 24, Issue 12, 17 December 2021, Pages 103442
[2]. Masibag, Angelique Noelline. Characterization of a New Peptidomimetic Compound Modulating Sam68 Functions in Human Colon Cancer Stem Cells. Diss. UniversitÉ d'Ottawa/University of Ottawa, 2021.

مراجعات

Review for YB-0158

Average Rating: 5 ★★★★★ (Based on Reviews and 20 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for YB-0158

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.