الصفحة الرئيسية>>Signaling Pathways>> GPCR/G protein>> OX Receptor>>YNT 185

YNT 185

رقم الكتالوجGC50559

YNT 185 هو ناهض لمستقبلات الأوركسين من النوع 2 غير الببتيد الانتقائي (OX2R) ، مع EC50s من 0.028 و 2.75 μ ؛ M لـ OX2R و OX1R ، على التوالي.

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YNT 185 التركيب الكيميائي

Cas No.: 1804978-82-2

الحجم السعر المخزون الكميّة
5mg
162٫00
متوفر
10mg
261٫00
متوفر
25mg
522٫00
متوفر
50mg
837٫00
متوفر

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مراجعات العميل

بناء على آراء العملاء.

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.

Nagahara et al (2015) Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J.Med.Chem. 58 7931 PMID:26267383 |Irukayama-Tomobe et al (2017) Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc.Natl.Acad.Sci.USA. 144 5731 PMID:28507129

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