YNT 185 |
| Catalog No.GC50559 |
YNT 185 est un agoniste sélectif non peptidique du récepteur de l'orexine de type 2 (OX2R), avec des CE50 de 0,028 et 2,75 μM pour OX2R et OX1R, respectivement.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1804978-82-2
Sample solution is provided at 25 µL, 10mM.
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Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.
Nagahara et al (2015) Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J.Med.Chem. 58 7931 PMID:26267383 |Irukayama-Tomobe et al (2017) Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc.Natl.Acad.Sci.USA. 144 5731 PMID:28507129
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