YS-370 |
| رقم الكتالوجGC65184 |
YS-370 (المركب 44) هو مثبط فعال وعالي الانتقائي وفعال عن طريق الفم للبروتين P-glycoprotein (P-gp)يحفز YS-370 نشاط P-gp ATPase وله تثبيط معتدل ضد CYP3A4يعكس YS-370 بشكل فعال مقاومة الأدوية المتعددة (MDR) لباكليتاكسيل وكولشيسين في خلايا SW620 / AD300 و HEK293T-ABCB1YS-370 بالاشتراك مع باكليتاكسيل يحقق نشاطًا مضادًا للأورام أقوى بكثير
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2470908-79-1
Sample solution is provided at 25 µL, 10mM.
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YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity[1].
[1]. Yuan S, et al. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors. J Med Chem. 2021;64(19):14895-14911.
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