YS-370 |
| Catalog No.GC65184 |
YS-370 (composé 44) est un inhibiteur puissant, hautement sélectif et oralement actif de la glycoprotéine P (P-gp). YS-370 stimule l'activité P-gp ATPase et a une inhibition modérée contre le CYP3A4. YS-370 inverse efficacement la multirésistance aux médicaments (MDR) au paclitaxel et À la colchicine dans les cellules SW620/AD300 et HEK293T-ABCB1. YS-370 en combinaison avec le paclitaxel atteint une activité antitumorale beaucoup plus forte.
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Cas No.: 2470908-79-1
Sample solution is provided at 25 µL, 10mM.
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YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity[1].
[1]. Yuan S, et al. Discovery of New 4-Indolyl Quinazoline Derivatives as Highly Potent and Orally Bioavailable P-Glycoprotein Inhibitors. J Med Chem. 2021;64(19):14895-14911.
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