Z 944 |
| رقم الكتالوجGC50432 |
Z 944 هو مضاد لقنوات الكالسيوم من النوع T النشط عن طريق الفم والذي ينقذ الضعف في ذاكرة التعرّف البصري والوسائط المتقاطعة.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1199236-64-0
Sample solution is provided at 25 µL, 10mM.
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Selective T-type Ca2+ channel blocker (IC50 values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3). Exhibits 50 to 600 fold selectivity for Cav3.x channels over related ion channels (Cav1.2, hERG and Nav1.5). Has no effect on action potential properties in isolated heart Purkinje fibers and no adverse effects on ECG parameters in vivo. Exhibits anti-seizure effects in animal models.
Tringham et al (2012) T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Sci.Transl.Med. 4 121 PMID:22344687 |Casillas-Espinosa et al (2015) Z944, a novel selective T-type calcium channel antagonist delays the progression of seizures in the amygdala kindling model. PLoS One. 10 e0130012 PMID:26274319
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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