CK2-TN03 |
Katalog-Nr.GC79111
One-Click Copy Product Info
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CK2-TN03 is an ATP-competitive casein kinase 2 ( CK2 ) inhibitor, with an IC50 of 165 nM and a K i of 20 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 313226-24-3
Sample solution is provided at 25 µL, 10mM.
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In Vivo, CK2-TN03 (40 mg/kg; i.p.; once daily; 28 days) significantly reduces neuroblastoma xenograft tumor growth and improves mouse survival, with a subset of mice achieving long-term tumor control or remission[1].
In Vitro, CK2-TN03 (0.2-25.0 μM; 48 h) induces dose-dependent cell death in the medulloblastoma DAOY cell line and multiple neuroblastoma cell lines, with EC50 values ranging from 0.31 to 1.95 μM; it shows no activity in glioblastoma U87 cells (EC50 >25 μM)[1]. CK2-TN03 (0.35-1.0 μM; 48 h) activates caspase 3/7 in CHP-212 neuroblastoma cells in a time-dependent manner, and primarily induces caspase-dependent apoptosis[1]. CK2-TN03 (0.5-1.0 μM; 24-48 h) induces G2/M cell cycle arrest and subsequent cell death in CHP-212 neuroblastoma cells[1]. CK2-TN03 (0.5 μM; 24 h) arrests CHP-212 neuroblastoma cells in mitosis, blocks successful cell division, and induces mitotic catastrophe and cell death[1]. CK2-TN03 (0.5 μM; 48 h) downregulates the activity and expression of survivin in CHP-212 neuroblastoma cells by directly inhibiting CK2-mediated phosphorylation of survivin and indirectly altering the AKT1/MDM2/p53 and BRD4/MYCN pathways, without changing the expression of CK2[1]. CK2-TN03 (0.5 μM; 48 h) does not affect the viability of differentiated quiescent SH-SY5Y neuroblastoma cells, which exhibit low survivin expression levels[1]. CK2-TN03 (1-10 μM; 72 h) induces cell death in a diverse panel of 160 cancer cell lines, with significant tumor entity selectivity, and exhibits the highest potency against melanoma, lymphoma, lung cancer, neuroblastoma, ovarian cancer, myeloma, soft tissue cancer and osteosarcoma cell lines[1]. CK2-TN03 (10 μM; 1 h) exhibits excellent permeability in MDCKII-MDR1 cells, with negligible efflux and no P-gp substrate activity[1].
References:
[1]. Cazzanelli G, et al. Switching off CK2-mediated activation of survivin offers new therapeutic opportunities in neuroblastoma. Exp Mol Med. 2026;58(1):227-242.
| Cas No. | 313226-24-3 | SDF | |
| Formula | C17H14N2O3S | M.Wt | 326.37 |
| Löslichkeit | DMSO: 83.33 mg/mL (255.32 mM; Need ultrasonic) | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.064 mL | 15.32 mL | 30.6401 mL |
| 5 mM | 612.8 μL | 3.064 mL | 6.128 mL |
| 10 mM | 306.4 μL | 1.532 mL | 3.064 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)