TAE648 is a target protein ligand of PROTAC SK-3-91 ( Ligand for Target Protein for PROTAC ). TAE648 can be used for synthesis PROTAC [1]. TAE648 decreases monolayer-cultured SKOV3ip1 cell viability [2].
References:
[1]. Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020;183(6):1714-1731.e10.
[2]. Cha HJ, et al. Selective FGFR inhibitor BGJ398 inhibits phosphorylation of AKT and STAT3 and induces cytotoxicity in sphere-cultured ovarian cancer cells. Int J Oncol. 2017 Apr;50(4):1279-1288.
[3]. Hellwig S, et al. Small-molecule inhibitors of the c-Fes protein-tyrosine kinase[J]. Chemistry & biology, 2012, 19(4): 529-540.
References:
[1]. Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020;183(6):1714-1731.e10.
[2]. Cha HJ, et al. Selective FGFR inhibitor BGJ398 inhibits phosphorylation of AKT and STAT3 and induces cytotoxicity in sphere-cultured ovarian cancer cells. Int J Oncol. 2017 Apr;50(4):1279-1288.
[3]. Hellwig S, et al. Small-molecule inhibitors of the c-Fes protein-tyrosine kinase[J]. Chemistry & biology, 2012, 19(4): 529-540.