Membrane Transporter/Ion Channel

HCM-01 is an Excitatory amino acid transporter 2 ( EAAT2 ) activator with oral effectiveness and blood-brain barrier penetration.HCM-01 binds to the allosteric site of EAAT2, increases EAAT2 expression in astrocytes, enhances glutamate-handling capacity, and modulates glutamate homeostasis.HCM-01 acts as an antioxidant, improves oxidative/antioxidative balance and increases total antioxidant capacity.

2-Amino-2-deoxy-D-glucopyranose is an isomeric form of Glucosamine.

Piezo1 agonist 2 (Compound PD2) is a blood-brain barrier-permeable Piezo1 agonist and Jedi2 conjugate that utilizes LAT1.

Anti-ZnT8 Antibody (mAb43) is a monoclonal antibody targeting the zinc transporter ZnT8, with islet-specific biodistribution characteristics.

Atidafonat is an orally active sodium-dependent phosphate transporter inhibitor, with IC 50 values of 6.8, 1.5, and 1.7 μM against human NaPi-IIb, PiT-1, PiT-2, respectively; and IC 50 values of 3.9, 1.9, and 1.7 μM against rat NaPi-IIb, PiT-1, PiT-2, respectively.

S-D-Lactoylglutathione (S-Lactylglutathione; (R)-S-Lactoylglutathione) is a multifunctional metabolic intermediate of the glyoxalase system.

YHV98-4 is a selective, blood-brain barrier-permeable Hv1 inhibitor with an IC 50 of 0.7 μM.

AM9053 is a selective, effective and slowly reversible inhibitor of N-acyl ethanolamine acid amidease ( NAAA ) ( IC 50 = 30 nM).

Hepcidin antagonist-1 (example 104) is a potent hepcidin (hepcidine) antagonist with an IC 50 <50 μM.

Ivabradine is a potent and orally active HCN (hyperpolarization-activated cyclic nucleotide-gated) channel blocker that inhibits the cardiac pacemaker current (If).

pan-HCN-IN-1 is a potent HCN ion channel inhibitor with IC 50 values of 58 nM, 522 nM, 58 nM, and 58 nM against HCN1, HCN2, HCN3, and HCN4, respectively.

Saviprazole (HOE-731) is a H +,K + -ATPase inhibitor.

Pyrimidinone 8 is a reversible linear non-competitive inhibitor of divalent metal transporter 1 ( DMT1 ), with a K i of 20 μM ( hDMT1 ).

TRPV1 antagonist 10 is an orally active and potent TRPV1 antagonist ( IC 50 = 33.06 nM), moderate to weak URAT1 ( IC 50 = 22.51 μM) and GLUT9 (60.25% at 50 μM) inhibitor.

VUANT1 (VU0183254) is an allosteric antagonist of insect odorant receptor ion channels, which has the activity of inhibiting insect odorant receptor signaling.

TTFB (N-(4-tert-butyl-1,3-thiazol-2-yl)-3-fluorobenzamide) is a selective, non-competitive zinc-activated channel ( ZAC ) antagonist.

UCB1244283 is a synaptic vesicle glycoprotein 2A ( SV2A ) allosteric modulator.

URAT1 inhibitor 7 (compound 10f) is a potent URAT1 inhibitor, with an IC 50 of 12 nM.

ABC transporter modulator-1 (Compound I-5) is an ABC transporter expression enhancer.

ABC transporter modulator-2 (Compound I-200) is a ABC transporter expression modulator.

ABCC6 modulator-3 (Compound I-71) is a ABCC6 activator with an EC 50 < 1 μM.

(+)-Talinolol is an isomer of Talinolol.

ICA604025 is a state-dependent inhibitor of human Nav1.9 voltage-gated sodium channel.

Piezo1 agonist 2 hydrochloride is a blood-brain barrier-permeable Piezo1 agonist and Jedi2 conjugate that utilizes LAT1.