HCN Channel
Hyperpolarization- and Cyclic Nucleotide-gated (HCN) channels are a family of six transmembrane domain, single pore-loop, hyperpolarization activated, non-selective cation channels. The HCN family consists of four members (HCN1-4). HCN channels represent the molecular correlates of I(h), a hyperpolarization-activated current best known for its role in controlling heart rate and in the regulation of neuronal resting membrane potential and excitability.
HCN channels are unique among vertebrate voltage-gated ion channels, in that they have a reverse voltage-dependence that leads to activation upon hyperpolarization. HCN channels are encoded by four genes (HCN1-4) and are widely expressed throughout the heart and the central nervous system.
Targets for HCN Channel
Products for HCN Channel
- Cat.No. 상품명 정보
- GC18503 DK-AH 269 실로브라딘은 HCN 채널 차단제입니다. 뉴런 Ih 및 관련 심장 If 채널의 개방 채널 차단제.
- GC32491 Zatebradine (UL-FS49) 자테브라딘(UL-FS49)(UL-FS-49(유리 염기), UL-FS-49CL(유리 염기))은 IC50 값이 1.96 μ인 과분극 활성화 순환 뉴클레오티드 개폐(HCN) 채널의 강력한 억제제입니다. ;중.
- GC16965 Zatebradine hydrochloride Zatebradine(UL-FS-49(유리 염기))은 IC50 값이 1.96μM인 과분극 활성화 순환 뉴클레오티드 게이트(HCN) 채널의 강력한 억제제입니다.
- GC10578 ZD 7288 ZD 7288(ICI D7288)은 선택적 과분극 활성화 순환 뉴클레오티드 게이트(HCN) 채널 차단제입니다.