1,10-Phenanthroline (hydrate)
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| Catalog No.GC45978 |
El monohidrato de o-fenantrolina (1,10-fenantrolina), un quelante de metales, previene la inducciÓn de aberraciones cromosÓmicas en las células tratadas con estreptozotocina.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5144-89-8
Sample solution is provided at 25 µL, 10mM.
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1,10-Phenanthrine is a metal chelator and inhibitor of metalloproteases.1,2,3 It inhibits zinc-dependent hydrolysis of Fa-Gly-Leu-NH2 by B. subtilis neutral protease and B. thermoproteolyticus thermolysin.1 1,10-Phenanthrine is fungistatic against P. verrucosa (MIC = 0.8 μg/ml) and inhibits zinc-induced P. verrucosa metallo-type peptidase activity in a concentration-dependent manner.2 It induces uncoupling of and inhibits egg production by adult S. mansoni worm pairs in vitro when used at concentrations ranging from 0.5 to 150 μM.3 1,10-Phenanthrine (20 mg/kg per day) reduces worm burden in a mouse model of S. mansoni infection.
|1. Feder, J., Garrett, L.R., and Kochavi, D. Studies on the inhibition of neutral proteases by 1,10-phenanthroline. Biochim. Biophys. Acta 235(2), 370-377 (1971).|2. Granato, M.Q., Massapust, P.d.A., Rozental, S., et al. 1,10-Phenanthroline inhibits the metallopeptidase secreted by Phialophora verrucosa and modulates its growth, morphology and differentiation. Mycopathologia 179(3-4), 231-242 (2014).|3. Day, T.A., and Chen, G.-Z. The metalloprotease inhibitor 1,10-phenanthroline affects Schistosoma mansoni motor activity, egg laying and viability. Parasitology 116(Pt. 4), 319-325 (1998).
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