12(R)-HETE (Synonyms: 12(R)-Hydroxyeicosatetraenoic Acid) |
| Catalog No.GC40447 |
Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid.
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Cas No.: 82337-46-0
Sample solution is provided at 25 µL, 10mM.
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Biosynthesis of 12(R)-HETE in invertebrates is via lipoxygenation of arachidonic acid . In mammals, 12(R)-HETE can be produced by 12(R)-LOs and also by CYP450 oxidation. The activity of 12(R)-HETE in mammals is predominantly proinflammatory. 12(R)-HETE exhibits dose-dependent leukocyte chemotaxis at concentrations as low as 100 nM, and lowers intraocular pressure in rabbits.
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