α-Conotoxin PnIA (trifluoroacetate salt) (Synonyms: α-CtxPnIA, αPnIA) |
| Catalog No.GC52338 |
A peptide antagonist of α3β2-subunit containing and α7 nAChRs
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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α-Conotoxin PnIA is a peptide originally isolated from the venom of the marine mollusk C. pennaceus and an antagonist of α3β2 subunit-containing nicotinic acetylcholine receptors (nAChRs) and α7 nAChRs (IC50s = 7.9 and 62.7 nM, respectively).1,2 α-Conotoxin PnIA (0.1 nmol/kg) in combination with baicalein inhibits tumor growth and increases survival in an Ehrlich murine spontaneous adenocarcinoma model.3
1.Fainzilber, M., Hasson, A., Oren, R., et al.New mollusc-specific α-conotoxins block Aplysia neuronal acetylcholine receptorsBiochemistry33(32)9523-9529(1994) 2.Hopping, G., A., W.C.-I., Hogg, R.C., et al.Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptorsBiochem. Pharmacol.91(4)534-542(2014) 3.Osipov, A.V., Terpinskaya, T.I., Yanchanka, T., et al.α-Conotoxins enhance both the in vivo suppression of Ehrlich carcinoma growth and in vitro reduction in cell viability elicited by cyclooxygenase and lipoxygenase inhibitorsMar. Drugs18(4)193(2020)
| Cas No. | SDF | ||
| Sinónimos | α-CtxPnIA, αPnIA | ||
| Canonical SMILES | OC(C[C@H](NC([C@@H]1CCCN1C([C@H](CC(N)=O)NC([C@H](CC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](CSSC2)NC([C@@H]3CCCN3C([C@@H]4CCCN4C([C@@H](NC([C@H](CO)NC([C@H]5NC([C@H]2NC(CN[H])=O)=O)=O)=O)CC(C)C)=O)=O)=O)=O)C)=O)C)=O)=O)=O)=O)C(N[C@@H](CC(C=C6)=CC=C6O)C(N[C@@H](CSSC5)C(N)=O)=O)=O)=O.OC(C(F)(F)F)=O | ||
| Formula | C65H95N19O22S4 ? XCF3COOH | M.Wt | 1622.8 |
| Solubility | Water: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.6162 mL | 3.0811 mL | 6.1622 mL |
| 5 mM | 0.1232 mL | 0.6162 mL | 1.2324 mL |
| 10 mM | 0.0616 mL | 0.3081 mL | 0.6162 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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