AP-1/NF-κB activation inhibitor 1 |
| Catalog No.GC61970 |
El inhibidor de activaciÓn 1 de AP-1/NF-κB es un potente inhibidor de activaciÓn transcripcional mediado por AP-1 y NF-κB (IC50=1 μM), sin bloquear la transcripciÓn basal impulsada por el promotor de actina β.
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Cas No.: 188936-12-1
Sample solution is provided at 25 µL, 10mM.
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AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells[1].
[1]. Palanki MS, et al. Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett. 2000;10(15):1645-1648.
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