AZD4721 (Synonyms: AZD4721; RIST4721) |
| Catalog No.GC64312 |
AZD4721 (RIST4721) es el antagonista potente y activo por vÍa oral del receptor Ácido de quimiocinas CXC 2 (CXCR2).
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Cas No.: 1418112-77-2
Sample solution is provided at 25 µL, 10mM.
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AZD4721 (RIST4721) is the potent and orally active antagonist of acidic CXC chemokine receptor 2 (CXCR2). AZD4721 has the potential for the research of inflammatory disease[1].
Assessment of Pharmacokinetics (PK) profile of AZD4721 (RIST4721) in rat and dog[1]. In Vivo PK Rat Dog Predicted hepatic metabolic CL (ml/min per kilogram)1.70.80 Observed CL (ml/min per kilogram)2.40.50 CLrenal (mL/min per kilogram)biliary (mL/min per kilogram)intc1.40.6 VSS (l/kg)0.190.15 T1/2 (h) (PO)1.33.7 (2.7)(8.4) F (%)4582
[1]. Gardiner P, et al. Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs. Drug Metab Dispos. 2019;47(8):865-873.
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