BR351 precursor |
| Catalog No.GC33365 |
El precursor de BR351 es un precursor de BR351. BR351 es un inhibidor de MMP penetrante en el cerebro con IC50 de 4, 2, 11, 50 nM para MMP2, MMP8, MMP9 y MMP13, respectivamente.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 960113-89-7
Sample solution is provided at 25 µL, 10mM.
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BR351 precursor is a precursor of BR351. BR351 is a brain penetrant MMP inhibitor with IC50s of 4, 2, 11, 50 nM for MMP2, MMP8, MMP9 and MMP13, respectively[1]. Potential tools for the molecular imaging of activated MMPs with PET[2].
[1]. Wagner S, et al. Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem. 2007 Nov 15;50(23):5752-64. [2]. Vazquez N, et al. Evaluation of [18 F]BR420 and [18 F]BR351 as radiotracers for MMP-9 imaging in colorectal cancer. J Labelled Comp Radiopharm. 2017 Jan;60(1):69-79.
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